Category: "Biology"

Coding Phases / Frames

April 17th, 2008
The phase (or sometimes called frame) gives information on how to translate individual parts of a gene, the coding exons. Phases 1 & 2 have a different definition in GFF and EnsEMBL format! In EnsEMBL, the phase is defined for exon objects like this:… more »

Nonsense-mediated Decay

March 12th, 2008
Nonsense mediated decay (NMD) is a cellular mechanism of mRNA surveillance to detect nonsense mutations and prevent the expression of truncated or erroneous proteins. NMD is triggered by exon-junction complexes (EJC), that have been formed during… more »

GENCODE

February 28th, 2008
GENCODE is a scientific project in the area of genome research. Research Goal: Annotate gene features across the human genome using computational methods, manual annotation, and targeted experiments as part of the ENCODE project. Grant proposal: Tim… more »